Opportunity Information: Apply for RFA RM 18 016
The funding opportunity titled "Innovative Technologies to Deliver Genome Editing Machinery to Disease-relevant Cells and Tissues (UG3/UH3 Clinical Trial Not Allowed)" (Funding Opportunity Number RFA RM 18 016) is a National Institutes of Health (NIH) cooperative agreement program under the U.S. Department of Health and Human Services. It sits in the health funding activity category (CFDA 93.310) and was created on January 24, 2018, with an original application closing date of April 3, 2018. The central aim is to speed progress toward genome editing-based treatments by tackling one of the biggest bottlenecks in the field: getting genome editing tools into the right somatic (non-reproductive) cells and tissues in a way that is efficient, safe, and practical for future therapeutic use.
At its core, the FOA is designed to support the development and evaluation of innovative delivery approaches for genome editing machinery. In practical terms, that means research teams are expected to work on methods that can transport and introduce genome editing components (for example, programmable nucleases and associated guide or template elements) into cells and tissues that matter for a specific disease context. The focus on "disease-relevant cells and tissues" signals that projects should be anchored in realistic biological targets rather than purely theoretical or generic delivery demonstrations. The long-term objective is to accelerate the path from lab advances to genome editing therapeutics that could treat human disease, but the FOA explicitly indicates that clinical trials are not allowed under this mechanism, keeping the scope in the preclinical and translational technology-development space.
The award mechanism is a cooperative agreement, which typically means NIH expects substantial involvement during the project, such as scientific coordination, milestone-based management, and ongoing programmatic input. The activity uses the UG3/UH3 structure, a common NIH phased approach where an initial stage supports planning, feasibility, and early development (UG3), and a subsequent stage supports more advanced development and rigorous evaluation (UH3), usually contingent on meeting pre-specified milestones. This structure strongly encourages clear go/no-go decision points, measurable progress, and a development mindset rather than open-ended basic research.
Funding details include an award ceiling of $500,000 and an anticipated total of about 10 awards. While the posted ceiling is a key constraint, cooperative agreement programs also tend to emphasize deliverables, reproducible performance metrics, and data packages that enable downstream translation. Applicants would generally be expected to propose concrete evaluation plans for delivery performance in relevant models, such as demonstrating that the delivery system can reach targeted tissues, achieve functional genome editing outcomes, and do so with acceptable tolerability and specificity for the intended use case, while remaining within the non-clinical scope.
Eligibility is broad and includes many types of domestic organizations and government entities. Eligible applicants listed include state, county, city or township governments, special district governments, and independent school districts; public and state-controlled institutions of higher education and private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where applicable); for-profit organizations other than small businesses, as well as small businesses; and other applicants as described in the FOA's additional eligibility text. This wide eligibility suggests NIH was aiming to attract a mix of academic innovators, nonprofit research groups, and private-sector developers who may have specialized capabilities in delivery technologies, formulation, biomaterials, vector engineering, device-enabled delivery, or scalable manufacturing concepts.
Overall, the opportunity is best understood as a targeted push to solve delivery challenges that stand between genome editing methods and real-world therapeutic impact. Rather than funding clinical testing, it supports the kind of enabling technology development and rigorous preclinical evaluation that can de-risk future therapeutic programs and make genome editing approaches more practical, tissue-specific, and effective for treating human disease.Apply for RFA RM 18 016
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovative Technologies to Deliver Genome Editing Machinery to Disease-relevant Cells and Tissues (UG3/UH3 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Jan 24, 2018.
- Applicants must submit their applications by Apr 03, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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