Technical Assistance to Strengthen Health Information System Capacity in Ethiopia under the President's Emergency Plan for AIDS Relief (PEPFAR) | CDC RFA GH22 2245

Opportunity Information: Apply for CDC RFA GH22 2245

This grant opportunity, titled "Technical Assistance to Strengthen Health Information System Capacity in Ethiopia under the President's Emergency Plan for AIDS Relief (PEPFAR)" (Funding Opportunity Number: CDC RFA GH22 2245), is a CDC cooperative agreement focused on strengthening Ethiopia's health information systems to better support HIV program monitoring and epidemic control. It sits under the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), within the health funding activity category (CFDA 93.067). The opportunity was posted on December 30, 2021, with an application deadline of February 28, 2022 (applications due by 11:59 pm ET). Eligibility is listed as unrestricted, meaning a wide range of entities can apply, subject to any additional eligibility language in the full notice.

Funding is described in a somewhat unusual way: the award ceiling for Year 1 is listed as 0 (none), yet CDC indicates it anticipates approximately $7,000,000 in total Fiscal Year funding for Year 1, dependent on the availability of funds. The NOFO also signals that CDC expects to make about two awards. As a cooperative agreement, the structure implies substantial involvement from CDC in collaboration with recipients, typically including technical direction, joint planning, and ongoing coordination rather than a hands-off grant model.

Programmatically, the core purpose is to maintain continuity of PEPFAR-supported health information systems in Ethiopia while upgrading and enhancing those systems toward globally and nationally recommended web-based solutions that meet both Ethiopia's Ministry of Health (MoH) requirements and PEPFAR reporting and performance needs. A major emphasis is on implementing digital health solutions that produce high-quality, individual-level strategic information. That kind of data is essential for tracking progress toward the HIV 95-95-95 targets (diagnosed, on treatment, virally suppressed) and for improving day-to-day program decisions, from facility performance to national-level resource planning.

The opportunity is explicitly aligned with Ethiopia's national digital health strategy, the country's eHealth architecture, and the Information Revolution Roadmap. In practical terms, that alignment signals that applicants are expected to work within national standards and frameworks, avoid building parallel systems, and prioritize interoperability and long-term fit within government-led digital health governance. The NOFO also highlights sustainability beyond PEPFAR funding, meaning it is not only about deploying software or improving reporting in the short term, but also about leaving behind systems and practices that can be maintained locally with reduced dependence on external funding and foreign technical assistance.

Capacity building is a central theme. The NOFO stresses strengthening local capacity to define, develop, maintain, use, and evaluate health information systems that are efficient, high-quality, secure, sustainable, and interoperable. This suggests work that goes beyond technical upgrades into workforce development, institutional processes, documentation, standards adherence, data quality improvement routines, and the ability of local teams to operate and improve systems over time. Security and responsible data handling are also clearly emphasized, especially given the sensitivity of HIV-related information and the need to protect patient confidentiality.

Finally, the NOFO frames health information system strengthening as critical to nationwide case-based surveillance (CBS). As Ethiopia approaches HIV epidemic control, the need shifts toward more precise monitoring, including accurate patient-level data that can be de-duplicated and de-identified. The goal is to support a reliable view of the clinical cascade and enable CBS to function effectively at scale, which requires consistent identifiers or matching approaches, strong data quality, careful privacy protections, and systems that can share information appropriately across sites and levels of the health system. In short, this opportunity is aimed at ensuring Ethiopia has the digital and analytical backbone to measure and sustain HIV epidemic control, while building durable national capacity to run those systems well into the future.

• The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Technical Assistance to Strengthen Health Information System Capacity in Ethiopia under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
• This funding opportunity was created on Dec 30, 2021.
• Applicants must submit their applications by Feb 28, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• The number of recipients for this funding is limited to 2 candidate(s).
• Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.

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