Opportunity Information: Apply for CDC RFA CE19 1904

Overdose Data to Action (CDC RFA CE19 1904) is a three-year CDC cooperative agreement designed to help states and local jurisdictions strengthen how they track, understand, and respond to the opioid overdose epidemic. The core idea is that the crisis changes quickly, and public health agencies need more complete and timely information on prescribing patterns as well as nonfatal and fatal overdoses in order to see where the problem is growing, who is being affected, and which drugs or combinations are driving harm. Just as importantly, the opportunity emphasizes turning that data into action by giving jurisdictions the practical tools, partnerships, and capacity needed to target prevention and response strategies where they will have the greatest impact.

This funding opportunity consolidates and continues work that had previously been supported under three separate CDC efforts: Prescription Drug Overdose Prevention for States (CE15-1501), the Data Driven Prevention Initiative (CE16-1606), and Enhanced State Surveillance of Opioid-Involved Morbidity and Mortality (CE16-1608). By integrating these streams, the program aims to create a more cohesive approach that links surveillance, prevention programming, and system-level interventions instead of treating them as disconnected projects. The overarching expectation is that recipients will improve the quality, completeness, and speed of overdose and prescribing data, then use those insights to guide evidence-informed interventions across healthcare, public health, and community partners.

A major focus is improving overdose surveillance so that jurisdictions can capture a clearer, faster picture of what is happening on the ground. This includes strengthening data systems that track both fatal overdoses (mortality) and nonfatal overdoses (morbidity), and improving the comprehensiveness and timeliness of those data so they are useful for decision-making rather than arriving too late to guide action. The program also prioritizes building state and local capacity to implement public health approaches that are considered promising based on research evidence, meaning recipients are expected to move beyond basic monitoring and into applying findings to real-world prevention strategies.

Another key component centers on Prescription Drug Monitoring Programs (PDMPs). The opportunity highlights making PDMPs easier to access and use, reflecting a practical barrier that often limits their effectiveness. By improving usability and access, the intent is to support better clinical decision-making and reduce risky prescribing and patient harm. Alongside PDMP improvements, awardees are encouraged to work directly with health systems, insurers, and community partners to improve opioid prescribing practices, aligning clinical care and payer policies with safer prescribing and better patient outcomes.

In addition to continuing these established areas of work, Overdose Data to Action adds new emphasis on linkages to care and other innovations supported by evidence-based practice. This reflects an acknowledgment that surveillance and prescribing improvements alone are not enough; jurisdictions also need mechanisms to connect people at risk (including those who have experienced nonfatal overdose) to effective services and treatment pathways. The program therefore supports activities that bridge public health data and response with care access, helping communities translate overdose events and risk patterns into timely outreach and connections to appropriate care.

Administratively, this is a discretionary funding opportunity offered by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), specifically within NCIPC, and it uses a cooperative agreement structure, which typically implies substantial CDC involvement and collaboration during implementation. Eligible applicants include state governments and local governments (county governments and city or township governments). The CFDA number is 93.136. The opportunity was created on February 1, 2019, with an original closing date of May 2, 2019, and applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. The anticipated scale was large, with an expected 78 awards and an award ceiling listed at $7,100,000.

  • The Department of Health and Human Services, Centers for Disease Control - NCIPC in the health sector is offering a public funding opportunity titled "Overdose Data to Action" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
  • This funding opportunity was created on Feb 01, 2019.
  • Applicants must submit their applications by May 02, 2019 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $7,100,000.00 in funding.
  • The number of recipients for this funding is limited to 78 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments.
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