Opportunity Information: Apply for PA 19 129
The NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required), funding opportunity number PA 19-129, is a discretionary NIH grant program meant to help exceptional postdoctoral researchers move more quickly and successfully into independent faculty careers. Its core goal is to strengthen the pipeline of NIH-supported investigators by supporting a structured transition from a mentored postdoctoral phase into a tenure-track or equivalent independent research position. In practical terms, it is designed for people who already have strong momentum as postdocs (with a research doctorate and/or clinical doctorate) and who are ready to develop as independent scientists, but who still benefit from a short, clearly defined period of mentorship before stepping fully into independence.
The award is structured in two phases that mirror that career progression. The first phase (the K99 mentored phase) supports the applicant while they are still in a postdoctoral or equivalent mentored position, focusing on targeted career development and the completion of research milestones that position them for independence. The second phase (the R00 independent phase) provides NIH support after the awardee secures an independent, tenure-track (or equivalent) faculty appointment, with the intention of jump-starting a competitive, self-sustaining research program. The overall emphasis is not just on doing a good project, but on launching a durable independent career, so reviewers expect a credible plan for training, productivity, and transition, plus a clear path to becoming competitive for future NIH funding as an independent principal investigator.
This specific FOA is intended only for applicants who will be the lead investigator of an independent clinical trial as part of their career development and research plan. That includes leading a full clinical trial, leading a clinical trial feasibility study, or leading a separate ancillary clinical trial tied to a larger parent trial. The key distinction is leadership and responsibility: the applicant is expected to be the person driving the trial, not simply gaining experience on a trial run by someone else. If an applicant is not planning to lead an independent clinical trial, or if they plan to participate in a clinical trial led by another investigator as a training experience, they are directed to apply to a companion FOA (listed in the text as xxxx) rather than this one.
Eligibility is broad on the institutional side, reflecting NIH-wide interest in supporting research careers across many settings. Eligible applicants include a wide range of U.S.-based organizations and government entities such as state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized), as well as Native American tribal organizations that are not federally recognized tribal governments. The FOA also calls out additional eligible organization types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.
At the same time, there are clear limits related to foreign participation. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) institutions are not eligible to apply as the applicant organization. In addition, non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as NIH defines them in the NIH Grants Policy Statement, are allowed, meaning parts of the work may be conducted with foreign involvement when appropriately justified and structured under NIH rules, even though the applicant organization itself must be domestic.
From an administrative standpoint, the opportunity is offered by the National Institutes of Health under a grant mechanism (FundingInstrumentType: Grant) and is categorized under funding activities spanning education and health, as well as related social services domains. The CFDA (now commonly referenced through Assistance Listing numbers) associated with this FOA includes multiple NIH program listings (93.172, 93.213, 93.233, 93.273, 93.279, 93.286, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.865, 93.866), reflecting that different NIH institutes and centers may participate depending on scientific topic and mission fit. The source data lists an original closing date of 2020-05-07, and it does not specify an award ceiling or expected number of awards in the provided excerpt, which typically means applicants must consult the full FOA and institute-specific guidance for budget and paylines expectations.
Overall, this FOA is best understood as a career-launch award for advanced postdocs who are ready to become independent investigators and who will personally lead an independent clinical trial (or closely related feasibility/ancillary trial) as a central part of their transition plan. It supports both the final stage of mentored development and the first critical years of independence, with the explicit aim of turning strong postdoctoral researchers into competitive, NIH-funded faculty-level principal investigators.Apply for PA 19 129
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172, 93.213, 93.233, 93.273, 93.279, 93.286, 93.398, 93.837, 93.838, 93.839, 93.840, 93.846, 93.865, 93.866.
- This funding opportunity was created on 2018-12-20.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Funding Opportunity |
|---|
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV Prevention Clinical Trials Network Leadership and Operations Center (UM1 Clinical Trial Required) Apply for RFA AI 19 005 Funding Number: RFA AI 19 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV/AIDS Clinical Trials Networks Statistical and Data Management Centers (SDMC) (UM1 Clinical Trial Required) Apply for RFA AI 19 002 Funding Number: RFA AI 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 19 022 Funding Number: RFA AI 19 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $350,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (U01 Clinical Trial Optional) Apply for RFA AI 19 023 Funding Number: RFA AI 19 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 135 Funding Number: RFA MH 20 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 120 Funding Number: RFA MH 20 120 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 140 Funding Number: RFA MH 20 140 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| "Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed) Apply for RFA TR 19 014 Funding Number: RFA TR 19 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed) Apply for RFA EB 19 001 Funding Number: RFA EB 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01 Clinical Trial not allowed) Apply for RFA EB 19 002 Funding Number: RFA EB 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Science of Behavior Change (SOBC) Resource and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA AG 20 024 Funding Number: RFA AG 20 024 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01 Clinical Trial Optional) Apply for RFA MH 20 310 Funding Number: RFA MH 20 310 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Clinical Sites for the ECHO IDeA States Pediatric Clinical Trials Network - 2 (UG1 Clinical Trial Required) Apply for RFA OD 19 026 Funding Number: RFA OD 19 026 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $275,000 |
| Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) Apply for PAR 19 375 Funding Number: PAR 19 375 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional) Apply for PAR 19 376 Funding Number: PAR 19 376 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on biopsychosocial factors of social connectedness and isolation on health, wellbeing, illness, and recovery (R01 Clinical Trials Not Allowed) Apply for PAR 19 373 Funding Number: PAR 19 373 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on biopsychosocial factors of social connectedness and isolation on health, wellbeing, illness, and recovery (R01 Basic Experimental Studies with Humans Required) Apply for PAR 19 384 Funding Number: PAR 19 384 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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