NHLBI Program Project Applications (P01) | PAR 16 402

Opportunity Information: Apply for PAR 16 402

The NHLBI Program Project Applications (P01) opportunity (Funding Opportunity Number PAR-16-402) is a discretionary NIH grant program run by the National Heart, Lung, and Blood Institute. It supports large, investigator-initiated research programs that bring together multiple, connected projects under one coordinated umbrella. The core idea is to fund a set of scientifically related studies that are stronger together than they would be as separate, stand-alone grants, with the expectation that the program is organized around a shared central theme, focus, and/or overall objective.

Scientifically, the FOA is broadly aligned with the NHLBI mission. Proposed programs can cover topics tied to the biology and diseases of the heart and blood vessels, lung biology and lung disease, blood-related biology and disorders, blood resources, and sleep disorders. Because it is investigator-initiated, applicants propose their own research questions and structure, as long as the work fits within NHLBI priorities and remains tightly integrated across the overall program.

A key structural requirement is that each application must include at least three related research projects. These projects are expected to be meaningfully interconnected, not just grouped together for administrative convenience. In practice, that means reviewers will look for a clear unifying rationale, complementary aims across projects, and a convincing explanation of how the combined effort advances the program theme more effectively than independent applications. While the provided summary emphasizes the minimum of three projects, the broader P01 concept typically implies program-level coordination and shared resources or leadership, so applicants should be prepared to demonstrate strong management and integration across the full set of studies.

Eligibility is expansive and includes many types of U.S.-based organizations and government entities. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

Foreign eligibility is restricted in a specific way. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S. applicant may include certain foreign collaborations or activities if they meet NIH’s definition and requirements for foreign components, even though a foreign institution cannot be the applicant organization.

From the funding metadata provided, the award ceiling is listed as $1,515,000. The FOA is associated with multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840), reflecting its placement within NIH/NHLBI assistance listings tied to heart, lung, blood, and sleep research areas. The opportunity was created on 2016-08-15, and the original closing date shown is 2017-09-25, which indicates the specific submission window for that posting.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Program Project Applications (P01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
• This funding opportunity was created on 2016-08-15.
• Applicants must submit their applications by 2017-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $1,515,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 16 402

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